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EUROPEAN ANTIBIOTIC AWARENESS DAY

A EUROPEAN HEALTH INITIATIVE

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This page contains simplified steps for building quickly .

If you downloaded the virtual machine disk image, skip this step.

BRL-CAD uses the CMake build system and may be built with most compilers, so first step is to download and install CMake . If needed, compiling from their source distribution is actually very easy.

If you're on a Mac or Windows, you're good to go. For Linux, BSD, and other package-managed systems, you'll want to install a few things.

If you downloaded the virtual machine disk image, run this to make sure you have the latest sources:

For everyone else, we recommend obtaining the latest sources from our repository:

If you run into trouble, snapshot release sources may also be obtained from Sourceforge .

Next, set up a build directory and configure your compilation:

By default, our build enforces code standards that will halt on trivial issues, so we recommend turning off that strict behavior for your first compile. By default, it will also search your system for dependencies, but this can be complicated so we tell the build to use our bundled versions. When you graduate to doing development, you'll want to change the build type to -DCMAKE_BUILD_TYPE=Debug instead of Release.

BRL-CAD source files contain an INSTALL file with more detailed instructions if you want to customize the build.

You're good to go, now it's time to compile:

Compilation can take anywhere from a couple minutes to an hour depending on your hardware. If you had a quad-core CPU, you might run '"make -j4" to request compiling in parallel.

If the build fails, re-run make while capturing all output to a log: make > build.log 2>1 Please report any build failures.

You don't have to install to run BRL-CAD. You can just run the binaries you just finished compiling. They are in the brlcad/.build/bin directory. There are 400+ tools in BRL-CAD. Here's a couple to get started:

The first command will evaluate your system performance. If you made a Release build, please submit your benchmark results to benchmark at brlcad dot org.

The second command runs the main graphical interface. Be sure to check out the extensive Popular Online Best Store To Get Anna Sui Woman Velvettrimmed Ruffled Floralprint Silkchiffon Mini Dress Black Size 6 Anna Sui Discount Ebay lCsMk
and Main_Page for tutorials.

The third runs our newer graphical interface that is under development.

Help make BRL-CAD better! There are many ways you can contribute to open source and you don't need to be an experienced programmer. We do need software developers, but we also need artists, writers, designers, and managers.

Download citation file:

© 2018 Oxford University Press

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Abstract

Antibodies to pneumococcus are thought to represent the primary mechanism of naturally acquired resistance to colonization. Here, however, we show that, in patients with chronic obstructive pulmonary disease (COPD), resistance to pneumococcal colonization is not associated with higher concentrations of serum anti-capsular or -noncapsular antibodies. We compared preacquisition serum antibody concentrations to capsular antigens 6B, 7F, 14, 19F, and 23F from patients with COPD who did and did not acquire pneumococcal respiratory tree colonization over the course of 2 years. Colonized patients did not have lower anti-capsular antibody concentrations than control subjects who did not acquire pneumococcus. We found no difference in functional antibody concentrations between colonized patients and control subjects. Furthermore, colonized patients had significantly higher preacquisition concentration of antibody directed against the whole cell and pneumococcal surface protein A than control subjects. We thus conclude that, in adult patients with COPD, resistance to pneumococcal colonization is unlikely to be determined by higher serum antibody concentrations to pneumococcal antigens.

Topic:
Issue Section:

Streptococcus pneumoniae is an important human pathogen causing asymptomatic carriage as well as important mucosal and systemic infections. Anti-capsular antibodies are thought to represent the single most important protective mechanism against invasive disease [ 1 ]. Antibodies to pneumococcal capsular polysaccharides were the basis of serum therapy in which passively transferred, serotype-specific antipneumococcal serum was shown to reduce mortality from pneumococcal pneumonia by half [ 2 ]. The development of pneumococcal polysaccharide vaccines for adults [ 3 ] and the efficacy of pneumococcal polysaccharide-protein conjugate vaccines in infants and children [ 4 , 5 ] have confirmed that antibodies to polysaccharide antigens can provide excellent protection against invasive disease caused by pneumococci of the same serotype as well as that caused by cross-reacting serotypes.

Whether these anti-capsular antibodies represent the mechanism whereby unimmunized individuals develop resistance to pneumococcal infection is less clear. We recently presented seroepidemiologic data that suggest otherwise: the risk of invasive pneumococcal disease in childhood decreases in parallel for many different serotypes (which suggests a serotype-transcending mechanism) and before naturally acquired anti-capsular antibodies are detectable [ 6 ]. Antibodies to other, noncapsular antigens have also been suggested to mediate acquired resistance to pneumococcal infection [ 7 , 8 ].

When Behance member Mustafa Aslan gives client his payment terms, he notes that he will first send a low-res preview of the finished work, for the client to approve and accept. Once the client has accepted the work, Alsan Georgia Midi Dress in Ivory size M also in LSXS Donna Mizani Lowest Price Huge Surprise For Sale With Mastercard Clearance Authentic Buy Cheap Buy p07eStnA6
It’s a clever way to conduct the transaction, especially when dealing with a new client. “This method is like the optimal way to secure a payment,” says Aslan. “It creates trust, because every time you get paid, you send them a proof about the work done.”

Pay yourself the equivalent of a salary, so you have a year-round income

For those whose earnings ebbs and flows throughout the year, it can be impossible to count on a regular income. So once you have built up a steady roster of existing clients, pay yourself a monthly “salary” that is one-twelfth of your annual earnings . A predictable pay structure allows you to work and live with the predictability and structure of a salaried employee.

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—whose clients include Target, Lexus and Apple—use this system at their two-person agency. Incoming checks are distributed among the various JUCO business expenses—including agent fees, taxes and overhead—and the rest is put in a compensation account. Gardo and Cloud then pay themselves the same amount every month, whether they did a $10,000 or $50,000 job that month. “We can’t have less than $40,000 in the account,” says Gardo. “That is so we know we are able to pay ourselves out.”

Sweat the small, nitpicky stuff related to money

Contracts, invoices, tax forms, expenses reports, budgets – no creative truly likes pouring through these kinds of documents. But think of them as the glue that holds your business together. As such, you’ve got to both continuously review and properly store them (and no, shoving them into the back of a drawer doesn’t count as “storing” them.) I like to use Friday afternoon when I’m tuckered out from my creative projects to firm up all of my loose financial ends – sending out invoices, tracking expenses, and combing through my contracts to make sure all is well and fair.

Of all the meetings you take, the recurring one focused on keeping your finances tidy is the arguably the most important. At least once a month sit down and review your finances so you’re aware of what’s coming in and going out. And, if you’re like me and you need an assist in the numbers / legal departments, you can always hire an accountant or lawyer to do it. That way you both protect your financial and operations flank, while freeing up your time for your creative pursuits.

The Best Creative Career Insights, Delivered Weekly.

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Matt McCue is the Editor-in-Chief of99U.He lives in New York City, but he is willing to travel long distances for a good meal. Find him @ Womenamp;aposs Briefs Second Skin Beige HEMA Discount Sale Online 6p8hP6c
or email him atmccue@adobe.com.

AMEC’S INTEGRATED EVALUATION FRAMEWORK

Welcome to the resource centre for AMEC’s new Integrated Evaluation Framework. This new special section of AMEC’s website has been put together to answer the most common challenges and pressures faced by communicators today as they look to prove their value in a rapidly evolving media landscape.

Many of the evaluation methods and techniques that the industry took for granted for so many years are no longer enough. As organisational silos are coming down, PR professionals are being asked to work across all forms of media and use, and measure, these new channels and tactics. Work must encompass paid, earned, shared and owned media. To be effective at our jobs, we now need to plan and measure our communications in a truly integrated manner.

To prove the value of communication in an age of accountability it is vital to move beyond measuring just the content (or ‘media’) analysis that largely sufficed for the previous 20 years. Now communication professionals must show the effect that their work has had on the objectives of their respective organisations.

AMEC’s new Integrated Evaluation framework shows how to do this.

The interactive element of the integrated evaluation framework will guide you through the process from aligning objectives to establishing a plan, setting targets and then measuring the outputs, outtakes, outcomes and impact of your work.

At each step of the process it provides additional information and suggests potential approaches and metrics that might be appropriate.

AMEC’s integrated evaluation framework provides a consistent and credible approach that works for organisations of all sizes but which can be tailored to very specific user cases and objectives. Anyone can use it, it is free and non-proprietary, allowing any organisation, be it university, in-house department, PR agency, or measurement company to benefit from its approach.

The integrated evaluation framework replaces both AMEC’s previous Valid Metrics and Social Media Measurement Frameworks. The industry now has one integrated approach to the measurement challenges of today.

This new framework shows how to ‘operationalise’ the Barcelona Principles and demonstrates how to turn Principles into action, and to finally prove the value of our work.

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and additional resources to bring measurement to life. This includes an evaluation ‘taxonomy’ which lists and explains for each step of the process the key steps required, the metrics and milestones and the methods that should be considered.

My thanks to Professor Jim Macnamara of the University of Technology Sydney for creating this valuable resource and sharing it with the AMEC community.

The new framework is a result of a lot of hard work by a lot of people and my sincere thanks are due to them all.

Richard Bagnall
https://twitter.com/richardbagnall

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